In vivo genome-wide CRISPR screens of human T cells in solid tumors identify CAR T cell targets

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Science

13 August 2026 at 12:29 am

In vivo genome-wide CRISPR screens of human T cells in solid tumors identify CAR T cell targets

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Summary

An in vivo model capable of recovering human T cells from solid tumors has been developed, enabling genome-wide CRISPR screens to identify targets for improving CAR T cell anti-tumor activity.

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